(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2 Purity (GC) ≥99.0% e.e ≥99.0%
Ruifu Chemical is the leading manufacturer of (S)-(+)-3-Hydroxytetrahydrofuran (CAS: 86087-23-2) with high quality. Please contact us by e-mail:alvin@ruifuchem.com
| Chemical Name | (S)-(+)-3-Hydroxytetrahydrofuran |
| Synonyms | (S)-Tetrahydrofuran-3-ol |
| Stock Status | In Stock, Commercial Production |
| CAS Number | 86087-23-2 |
| Molecular Formula | C4H8O2 |
| Molecular Weight | 88.11 |
| EINECS | 425-090-2 |
| Boiling Point | 80℃/15 mmHg (lit.) |
| Density | 1.103 g/mL at 25℃(lit.) |
| Refractive Index | n20/D 1.45(lit.) |
| Water Solubility | Soluble |
| Storage Temperature | Sealed, Store at Cool and Dry Place |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Shipping Conditions | Ambient |
| COA & MSDS | Available |
| Origin of Product | Shanghai, China |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | Colorless transparent to light yellow liquid | Colorless transparent liquid |
| Identification (By GC) | Retention time of the sample should match with the retention time of reference standard | Conforms |
| Water by Karl Fischer | ≤0.50% | 0.05% |
| Specific Rotation | +15.0°~ +20.0°(C=2,MeOH) | +18.2° |
| Optical Purity | ≥99.0% | 99.90% |
| Purity（GC） | ≥99.0% | 99.81% |
| (R)-(-)-3-Hydroxytetrahydrofyran | ≤0.15% | 0.05% |
| Related Substances | ||
| Any Other Impurity | ≤0.40% | 0.10% |
| Total Impurities | ≤1.0% | 0.19% |
| Conclusion | The product has been tested and complies with the given specifications | |
Package:Bottle, 25kg/drum, or according to customer's requirement.
Storage Condition:Keep the container tightly closed. Store in a cool, dry and well-ventilated warehouse.
Shipping:Deliver to worldwide by air, by sea, by FedEx. Provide fast and reliable delivery.
86087-23-2 - Risk and Safety:
Hazard Symbols Xi - Irritant
Risk Codes 36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39 - Wear suitable gloves and eye/face protection
UN IDs NA 1993 / PGIII
WGK Germany 3
HS Code 29321900
(S)-(+)-3-Hydroxytetrahydrofuran (CAS: 86087-23-2) is a useful pharmaceutical intermediate. (S)-(+)-3-Hydroxytetrahydrofuran is an intermediate to the AIDS drugs amprenavir and fosamprenavir. Additionally, it has been an intermediate to developmental drug substances, such as chemotherapy agents.
86087-23-2 - MOA:
1、 Test Methods
Add approximately 0.5g sample in 5ml methanol. Inject a methanol blank, followed
by the composite samples.
GC Conditions as follow:
Column: Agilent J&W Rtx-1 (30M*0.25mm*0.25um)
Lenth 30M, LD 0.25mm, film 0.25um
Injection Mode: Split
Injection Temp: 280℃
Column Flow: 1.0 ml/min (N2)
Purge Flow: 3.0ml/min (N2)
Split Ratio: 30
Column Temp: 60℃ hold 2minutes, 10℃/min to 90℃, hold 3minutes, 25℃/min
to280℃, hold 1.4minutes
Detector Type: FID
Detector Temp: 300℃
Method of derivatization: To a 100ml round-bottom flask with a magnetic stirring bar was
added (S)-(+)-3-hydroxytetrahydrofuran (0.088g, 1.0 mmol, 1.0 equiv), 4-Dimethylaminopyridine
(30mg) and CH2Cl2 (10ml). Pyridine (0.3 ml, 3.0 mmol, 3.0 equiv) was added via syringe. The
solution was cooled to 0℃ prior to addition of Ac2O (0.19 ml, 2.0 mmol, 2.0 equiv). The reaction
mixture was stirred for 12 hours at room temperature. The aqueous layer was extracted with ethyl
acetate (3 × 50 ml). The combined organic extracts were washed with water (50 ml), brine (50 ml)
and dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residual crude
product was purified by flash column chromatography.
Test Method of EE%
The derivative was used to test theEE% via GC.
GC Conditions as follow:
Column: BETA DEX 120 (30M*0.25mm*0.25um)
Lenth 30M, I.D. 0.25mm, film 0.25um
Injection Mode: Split
Injection Temp: 220℃
Column Flow: 0.6 ml/min (N2)
Purge Flow: 5.0ml/min (N2)
WXZKQA:007(HL008)
Split Ratio: 80
Column Temp: 60℃ hold 2 minutes, 4.5℃/min to 150℃, hold 0 minutes, 50℃/min to 200℃, hold 4minutes
Detector Type: FID
Detector Temp: 250℃
