Octreotide Acetate CAS 83150-76-9 Peptide Purity (HPLC) ≥98.0% API High Quality

Octreotide Acetate (Sandostatin) is a synthetic peptide analogue of the hormone somatostatin, it is a long-acting somatostatin analog indicated for symptomatic control in acromegaly and gastroenteropancreatic tumors. Other potential uses under investigation include diabetes, psoriasis and Alzheimer's disease. Octreotide Acetate (Sandostatin) is a synthetic peptide analogue of the hormone somatostatin. Its actions include inhibition of the pituitary secretion of growth hormone and an inhibition of pancreatic islet cell secretion of insulin and glucagon. Unlike somatostatin, which has a plasma half-life of a few minutes, Octreotide has a plasma elimination half-life of 1 to 2 hours. Excretion of the drug is primarily renal. Octreotide reduces gastrointestinal motility and inhibits contraction of the gall bladder.  

Peptide drugs Novartis Sandostatin (Octreotide Acetate), is a synthetic natural somatostatin octapeptide derivatives, it retains a pharmacological effect similar to that of somatostatin, and the effect is long-lasting. Indications for Octreotide Acetate include acromegaly; Alleviation of symptoms and signs associated with functional gastroenteropancreatic endocrine neoplasia; And efficacy in Carcinoid Tumors presenting with carcinoid syndrome, VIP tumors, and glucagon tumors. In addition, Octreotide Acetate for gastrinomas/Zollinger-Ellison syndrome (usually in combination with proton pump inhibitors or H2 receptor blockers), Insulinomas (preoperative prevention of hypoglycemia and maintenance of normal blood sugar), the effective rate of growth hormone releasing factor tumor is about 50%. 

Octreotide Acetate is a national health insurance Class B drug, which is a synthetic natural octapeptide derivative of somatostatin, compared with natural somatostatin, the half-life of somatostatin is obviously prolonged and has the same pharmacological effects, including inhibition of growth hormone function, inhibition of gastric acid, pancreatic enzyme, glucagon and insulin secretion, and reduction of visceral blood flow, decreased gastrointestinal motility. Compared with native somatostatin, octreotide has a long half-life, is more selective for inhibition of growth hormone secretion than for inhibition of insulin secretion, and does not cause rebound hypersecretion of the hormone. 1, Control surgery or radiation therapy can not adequately control the disease in patients with acromegaly symptoms and reduce the patient's growth hormone (GH) insulin-like growth factor -1(1GF-1) plasma levels. Sandostatin may also be used to treat patients with acromegaly who are unable or unwilling to undergo surgery, or to treat patients with acromegaly who have not yet had radiation therapy. 2. Alleviation of symptoms associated with functional gastroenteropancreatic (GEP) endocrine tumors such as carcinoid tumors with carcinoid syndrome manifestations. Sandostatin is not an anti-cancer drug and does not cure these patients. 3, Prevention of complications after pancreatic surgery. 4, Liver cirrhosis patients with gastric-esophageal variceal bleeding caused by emergency treatment, hemostasis and prevention of rebleeding, Sandostatin should be combined with endoscopic sclerotherapy and other special treatment.